Marvel: Crisis Protocol – Thanos provides players everything they need to add Thanos, the Mad Titan to their games of Marvel: Crisis Protocol. This expansion pack also introduces rules for a new multi-player game mode: Ultimate Encounters. In "Ultimate Encounter: Infinity Gauntlet", two players team up in one last desperate gamble to attempt to defeat Thanos before he can use all six Infinity Gems to fulfill his mad vision for the universe.

Marvel: Crisis Protocol – Thanos contains one Thanos miniature, one throne terrain feature, one character stat card, two tactic cards, six Infinity Gem cards, fourteen "Ultimate Encounter" cards, forty tokens, and an Ultimate Encounter rulebook.