Looney Tunes Mayhem is built around the "Mayhem System", a system for character vs. character team-based combat in which the most direct method for a team to gain VP is by KOing their opponents. Characters use items and powers to battle the enemy team, with battle damage changing each round based on the mayhem die. When a character is KOed, they are removed from the board and their opponent gains VPs, with the KOed character returning to play next round.